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カタログ番号 | 製品名 | 別名 | ターゲット |
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T80052 | Cathepsin B | ||
Cathepsin B, a cysteine protease, plays a role in various forms of programmed cell death, such as apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death [1]. | |||
T3420 | CA-074 methyl ester | Cathepsin B Inhibitor IV,CA-074Me | Cysteine Protease |
CA-074 methyl ester (Cathepsin B Inhibitor IV) is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects. | |||
T27989 | MDK0734 | Cathepsin B Inhinitor-42 | |
MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities. | |||
T28003 | MDK7677 | Cathepsin B Inhinitor-17,MDK 7677 | |
MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities. | |||
T10924 | Cysteine protease inhibitor-2 | Cysteine Protease | |
Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively. | |||
T6015 | Cathepsin Inhibitor 1 | Cysteine Protease | |
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. | |||
T21509 | CA 074 | Cysteine Protease | |
CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalom... | |||
T13288 | VBY-825 | Cysteine Protease | |
T37504L | Cathepsin D and E FRET Substrate acetate | ||
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E but not for B, H, or L. Cathepsin D and E FRET Substrate acetate can be used in mechanistic studies on cathepsins D and E studies... | |||
T16089 | MK-0674 | Cysteine Protease | |
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases. | |||
T1850 | Balicatib | AAE581 | Cysteine Protease |
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis. | |||
T15641 | K777 | APC-3316 | P450 , Cysteine Protease , CCR |
K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ... | |||
T16092 | L-873724 | Others | |
L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respective... | |||
T37053 | Z-(L-Arg)-AMC (hydrochloride) | ||
Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can b... | |||
T80739 | Z-FG-NHO-BzOME | ||
Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S, and papain [1]. | |||
T78186 | Ac-VLPE-FMK | Ac-Val-Leu-Pro-Glu(OMe)-CH2F | |
Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), functions as an inhibitor of both Cathepsin B (Cat-B) and Cathepsin L (Cat-L), and is utilized in research pertaining to the aggressiveness of cancer [1] [2]... | |||
T75367 | Z-Arg-Arg-4MβNA triacetate | ||
Z-Arg-Arg-4MβNA triacetate serves as a specific substrate for cathepsin B, resulting in the generation of the fluorescent end product 4MβNA, which exhibits an excitation wavelength (λ ex) of 355 nm and an emission wavele... | |||
T76599 | Ac-Leu-Val-Lys-Aldehyde | ||
Ac-Leu-Val-Lys-Aldehyde is a potent inhibitor of cathepsin B, exhibiting inhibitory concentration (IC50) values of 4 nM. It notably diminishes cell death in the striatum induced by quinolinic acid and leads to the accumu... | |||
T73220 | RO5461111 | ||
RO5461111, a highly specific and orally active Cathepsin S antagonist, exhibits potent inhibitory effects with IC50 values of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. It effectively suppr... | |||
T15064 | DBCO-NHCO-PEG4-NHS ester | Others | |
DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T38254 | Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base) | ||
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate selectively cleaved by cathepsins D and E at the Phe-Phe amide bond, without activity towards cathepsins B, H, or L. This specificity makes it an essent... | |||
T73554 | SPR38 | ||
SPR38, a potent inhibitor of the SARS-CoV-2 main protease, exhibits a Ki value of 0.260 μM. Additionally, it effectively inhibits human cathepsin L (hCatL) and human cathepsin B (hCatB), displaying Ki values of 1.92 μM a... | |||
T36942 | SSAA09E1 | SSAA09E1 | |
SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based ... | |||
TP2161 | Z-WEHD-FMK | Caspase | |
Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM). | |||
T73553 | SPR39 | ||
SPR39, a potent inhibitor of the SARS-CoV-2 main protease (Mpro), demonstrates inhibitory Ki values of 0.252 µM for SARS-CoV-2 Mpro, and 3.38 and 7.88 µM for human Cathepsin L (hCatL) and human Cathepsin B (hCatB) respec... | |||
T62494 | Cathepsin C-IN-5 | ||
Cathepsin C-IN-5 (compound SF38) is a potent, selective, and orally active inhibitor of Cathepsin C, demonstrating IC50 values of 59.9 nM for Cat C, and showing significantly lower potency against Cat L (4.26 µM), Cat S,... | |||
T6564L | Leupeptin | Leupeptin Ac-LL,NK-381 | |
Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), ... | |||
T21949 | Calpain Inhibitor XII | ||
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor targeting calpain I (μ-calpain) with a Ki value of 19 nM. It exhibits lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM)... | |||
T69297 | Leupeptin HCl | ||
Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin... | |||
T11864 | Iptacopan | LNP023 | Others |
Iptacopan (LNP023) is an inhibitor with high affinity for factor B. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T6564 | Leupeptin Hemisulfate | Serine Protease , Cysteine Protease | |
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc... | |||
TN1249 | 3-Epiursolic acid | Cysteine Protease , Immunology/Inflammation related | |
3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered p... | |||
T3417 | Amentoflavone | Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin | Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal |
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... | |||
TJS2216 | Aurantiamide acetate | Asperglaucide | Cysteine Protease |
Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide aceta... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-00731 | Cathepsin B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is A0A024R374. | |||
TMPY-02144 | Cathepsin B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Cathepsin B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.6 kDa and the accession number is P10605. | |||
TMPY-04503 | Cathepsin B Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
Cathepsin B Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.1 kDa and the accession number is F7FAT8. | |||
TMPH-01059 | Cathepsin B Protein, Human, Recombinant (GST) | Human | E. coli |
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobuli... | |||
TMPJ-00497 | CTSB Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, bot... | |||
TMPJ-00845 | CTSE Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is loca... | |||
TMPY-01644 | Cystatin S Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cystatin-S, also known as Cystatin-4, Salivary acidic protein 1, Cystatin-SA-III and CST4, is a secreted protein which belongs to thecystatin family. Cystatin-4 / CST4 is expressed in submandibular and sublingual sali... | |||
TMPJ-00869 | GLB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase ... | |||
TMPK-01413 | H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi) | Mouse | HEK293 Cells |
Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of... | |||
TMPK-01416 | HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 we... | |||
TMPK-01412 | HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 we... |